Nicotinamide Riboside Combo Improves Hepatic Profiles in NAFLD

Daily supplementation with a fixed dose combination of nicotinamide riboside, L-carnitine, L-serine, and N-acetyl cysteine significantly reduced liver fat, quelled oxidative stress, and improved liver enzyme profiles in a cohort of 31 patients with non-alcoholic fatty liver disease (NAFLD). Defined as hepatic fat accumulation of 5% or more, unrelated to alcohol consumption or other liver […]

Long Haul Covid: A Variant of Post-Viral Syndrome

Long-haul Covid has unique features, but essentially, it is a variant of post-viral syndrome. That’s good news because many of the features of post-viral syndrome are easily treated. Between 20% and 25% of all Covid patients have persistent symptoms of some sort. Those numbers are similar to what we see with Epstein-Barr virus (EBV) and […]

Clearing the Fog Around Mast Cell Activation Syndrome

Mast cell activation syndrome—a multi-system disorder characterized by aberrant activity of these key immune cells—is widely prevalent, and on the rise as the world becomes more toxic, infectious, and stressful, says Tania Tyles Dempsey, MD, a clinician who specializes in this common but mis-diagnosed problem. The syndrome differs from mastocytosis or mast cell cancers in […]

BREESI & QUEESI: Tips for Diagnosing MCAS

Mast cell activation syndrome (MCAS) is inherently complex, and it can manifest in a bewildering number of ways. Patients may experience waxing and waning symptoms in seemingly unrelated organ systems, with no obvious pattern. MCAS overlaps with other chronic syndromes such as Ehlers-Danlos (EDS), Postural Orthostatic Tachycardia Syndrome (POTS), and chronic fatigue/fibromyalgia. It’s a complicated […]

Processed Foods & Energy Drinks: A Public Health Emergency

Highly processed foods and energy drinks do more harm than good—and Americans have a huge appetite for them. That’s bad news for the future health of the country.  According to a new analysis of data from nearly 41,000 US adults, consumption of ultra-processed foods rose markedly from 2001 to 2018, accounting for nearly 60% of […]

Glycocalyx Restoration is Key for Lowering CVD Risk

Repair of the endothelial glycocalyx is a vital element in the restoration of cardiovascular health, according to Mark Houston, MD, director of the Hypertension Institute at Saint Thomas West Hospital, Nashville. The endothelial glycocalyx (EGX) —literally “sugar coating” in Greek—is a very thin gel-like layer that lines the luminal surface of the blood vessels. It […]

Uric Acid is Detrimental to Gut Health

“People who suffer from chronic elevated uric acid tend to harbor unhealthy biomes,” says neurologist David Perlmutter, MD.

In his latest book, Drop Acid: The Surprising New Science of Uric Acid, Perlmutter presents several studies showing that adverse changes in the gut microbiome directly relate to our ability to metabolize and eliminate uric acid (UA).

The intricate interplay between hyperuricemia and the gut microbiome is still a relatively new field of research. But it has already led to some interesting discoveries.

FDA & AMA Team Up to “CMEar” Dietary Supplements

If you want to understand why so many Americans distrust the Food and Drug Administration and the medical mainstream, look no further than the FDA’s new online medical education program on dietary supplements. Produced in collaboration with the American Medical Association, this three-part continuing medical education (CME) course—and I use that term loosely—is part of […]

In Memoriam: Stephen Sinatra, MD

We at Holistic Primary Care are saddened to learn of the passing of Dr. Stephen Sinatra, on Father’s Day 2022, just four months shy of his 76th birthday. A trailblazer in the field of metabolic cardiology, Dr. Sinatra was an exemplary physician, healer, and teacher. Though trained in the conventional biomedical paradigm, he realized early […]

Dropping (Uric) Acid with Dr. David Perlmutter

Conventional medical wisdom holds that uric acid is a harmless, inert form of metabolic waste, and most physicians were trained to see it as a “trivial, incidental byproduct of our normal biology.” But contemporary research reveals that this compound is “anything but meaningless or unworthy of our attention,” says neurologist David Perlmutter, MD. In his […]