Lemon Balm Improves Sleep Quality In Placebo-Controlled RCT

By Janet Gulland, Contributing Writer

Melissa officinalis, known colloqually as Lemon Balm, has a venerable history of use as a relaxant, anxiolytic, and sleep aid. A new study shows nightly supplementation with a phytosomal extract of this plant improved sleep quality in a cohort of people with insomnia (Photo: Cristina Ionescu/Shutterstock)

These days, a lot of people could use some help in improving their sleep. A phytosomal extract of Lemon Balm (Melissa officinalis) may be just the ticket for many of them.

Data from a recent double-blind crossover study of 30 people with chronic insomnia show that nightly supplementation with 400 mg of Melissa officinalis Phytosome® (Indena), taken 30 minutes prior to bedtime, markedly reduced composite Insomnia Severity Index (ISI) scores and increased the amount of time spent in restorative slow-wave sleep.

The findings were strong enough to prompt lead investigator Francesco Di Pierro, PhD, of the University of Insubria, Varese, Italy, to consider this form of M. officinalis a “viable alternative to pharmaceutical treatments for insomnia, offering a natural and potentially safer option for individuals seeking relief from sleep disorders.”

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HPC Video

Clinical Pearls for Weight-Health Wins, with Calocurb—A Natural GLP-1 Activator

Written by Erik Goldman

GLP-1 receptor agonists are transforming clinical practices and protocols for significant weight-health wins.

In this free webinar, you will learn the science behind a clinically-proven natural GLP-1 activator called Calocurb, and how it can be used with and without prescription medications. You’ll discover a supplement derived from hops, and clinically shown to reduce cravings by 40%, hunger by 30%, and average calorie intake by 18%.

Find out how this powerful dietary supplement can play a role in holistic patient care. Edward Walker PhD, of the New Zealand Institute of Plant & Food Research will present key findings from 14 years of clinical research and $30m investment in plant-based GLP-1 activation.

Renowned functional nutrition expert, Ashley Koff RD, will offer insight on the clinical use of Calocurb.

You’ll learn about:

  • The role of bitter taste receptors in the activation of GLP-1, CCK, and PYY
  • The levels of GLP-1, CCK, and PYY required for gut-brain connection
  • The science supporting Amarasate, a bitter hop extract, a key ingredient in the Calocurb formula.
  • The value of optimizing endogenous GLP-1 (and partner hormones) for all patients
  • Differentiating key nutritional needs for patients taking GLP-1 agonists, and those weaning off of them.

Sponsored by Calocurb

Edward Walker, PhD is a scientist and lecturer who believes that developing a healthy relationship with food is key to long-term wellness.  He completed his PhD at the University of Auckland on the antioxidant effects of berry fruits, and has continued to research how dietary plant compounds can improve health and wellness. Dr. Walker works at The New Zealand Institute of Plant and Food Research undertaking commercially-focused research on clinically validated nutraceutical products for human health applications.  He is also a guest lecturer at the University of Auckland on the topic of nutraceuticals and functional foods.  He has headed 14 years’ worth of clinical research on Amarasate, the active ingredient in Calocurb.

Ashley Koff, RD, is an award-winning personalized nutrition expert with 25+ years’ experience helping thousands of people achieve better health powered by better nutrition. As founder of The Better Nutrition Program (BNP), Koff helms a team of clinicians, coaches, and digital health experts delivering personalized nutrition at scale, and offering a GLP-1 practitioner protocol package to optimize patient outcomes. Koff is also the Nutrition Director for the University of California Irvine Susan Samueli Integrative Health Institute’s Integrative and Functional Medicine Fellowship. She’s the author of 2 books, with a third coming in January 2026.

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