Data from nearly 300,000 UK citizens tracked over an average of 10 years show that constant statin use results in a progressive loss of grip strength and lean muscle mass, independent of demographic, genetic, and lifestyle variables. (Image: ArtemisDiana/Shutterstock)
Analysis
of data from nearly 300,000 UK citizens tracked over a 20-year period shows a decline of up
to 25% in grip strength, and a 73% drop in appendicular lean mass (ALM), among
continuous statin users compared with people who’d never taken statins.
Grip strength
diminished by a mean of 0.315 kg per year from baseline among the statin users,
and ALM showed a parallel reduction of 0.057 kg per year. Notably, these
changes were independent of genetic predisposition to statin responsiveness, as
well as demographic variables including age, gender, BMI, and co-morbidities.
“Continuous
statin use is associated with a decline in muscle function and mass over time, irrespective
of genetic susceptibility to statin response,” writes lead investigator Mélissa
Gentreau, PhD, a Functional Pharmacologist at the Department of Surgical
Sciences, Uppsala University, Sweden.
Back at the turn of the 20th Century, physician-bacteriologist Robert Koch predicted that, “One day, man will have to fight noise as fiercely as cholera and the plague.” That day is definitely upon us. The detrimental impact of noise goes far beyond the obvious problem of hearing loss. Over the last decades, researchers have shown, […]
(This article was originally published on April 8, 2025 by www.undark.org) Two years ago, at a Stop & Shop in Rhode Island, the Danish neuroscientist and physician Henriette Edemann-Callesen visited an aisle stocked with sleep aids containing melatonin. She looked around in amazement. Then she took out her phone and snapped a photo to send […]
GLP-1 receptor agonists are transforming clinical practices
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Renowned functional nutrition expert, Ashley Koff RD, will offer insight on the clinical use of Calocurb.
You’ll learn about:
The role of bitter taste receptors in the activation of GLP-1, CCK, and PYY
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The science supporting Amarasate, a bitter hop extract, a key ingredient in the Calocurb formula.
The value of optimizing endogenous GLP-1 (and partner hormones) for all patients
Differentiating key nutritional needs for patients taking GLP-1 agonists, and those weaning off of them.
Edward Walker, PhD is a scientist and lecturer who believes that developing a
healthy relationship with food is key to long-term wellness. He completed his PhD at the University of
Auckland on the antioxidant effects of berry fruits, and has continued to
research how dietary plant compounds can improve health and wellness. Dr.
Walker works at The New Zealand Institute of Plant and Food Research
undertaking commercially-focused research on clinically validated nutraceutical
products for human health applications.
He is also a guest lecturer at the University of Auckland on the topic
of nutraceuticals and functional foods.
He has headed 14 years’ worth of clinical research on Amarasate, the
active ingredient in Calocurb.
Ashley Koff, RD, is an award-winning personalized nutrition
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the Nutrition Director for the University of California Irvine Susan Samueli
Integrative Health Institute’s Integrative and Functional Medicine Fellowship.
She’s the author of 2 books, with a third coming in January 2026.
