Chronic Disease

Platelets: How to Keep Them In the “Goldilocks” Zone

By Russell Jaffe, MD, Contributing Writer

Platelets may be tiny—on average they’re about 20% of the diameter of red blood cells—but they have huge impact on our health and wellbeing. Beyond their obvious role in blood clotting and wound healing, they are also important players in the immune system. More than we realize, optimal health depends on the platelets doing their […]

Plant Sterols: An Effective Alternative For Statin-Intolerant Patients

By Janet Gulland, Contributing Writer

A recently published case series from the University of Chicago underscores the value of plant sterol supplements for managing elevated cholesterol in statin-intolerant patients at moderate to high risk for cardiovascular disease. While statin therapy with accompanying lifestyle modification remains the preferred conventional intervention for treating dyslipidemias and reducing cardiovascular risk, many patients do not […]

Immune System “Fingerprinting” A Key to Understanding Autoimmunity

By Mark R. Engelman, MD & Chad Larson, NMD, DC

A recent study published in the journal Arthritis and Rheumatology, shows that the prevalence of antinuclear antibodies (ANA)– the most common biomarker of autoimmunity–has increased considerably in the United States in recent years. Researcher Gregg E. Dinse and colleagues at Social & Scientific Systems, Durham, NC, examined the prevalence of ANA positivity in human subjects […]

Optimizing the Brain-Microbiome Axis

By Erik Goldman

The promise of the “psychobiotic revolution” is that many of the underlying drivers of chronic mental illness can be reversed with relatively simple interventions. “We cannot change the genes in our cells. But we can change the genes in our microbiota. That can have a positive—or a negative—health benefit,” says Ted Dinan, MD, PhD, a […]

Psychobiotics: Your Brain on Friendly Flora

By Grant Jackson, MD

The typical human body contains roughly 1.5 kilograms of microorganisms. That’s about equal in weight to the average human brain. It’s an interesting equivalence, given what we are learning about the myriad ways in which the gut microbiome influences the brain and central nervous system. Many common mental illnesses, including severe depression and anxiety, are […]

Maintaining Resilience by Supporting Healthy Mitochondrial Function

By Erik Goldman

In recent years, researchers and medical practitioners alike have taken interest in a particular molecule known to be the master regulator of cellular metabolism — nicotinamide adenine dinucleotide (NAD+). NAD+ is a ubiquitous coenzyme involved in hundreds of metabolic processes, including: mitochondrial energy production, glycolysis, and DNA synthesis and repair. It also plays a vital […]

Rx Omega-3 No Better Than Corn Oil for Preventing CV Events

By Erik Goldman

Astra-Zeneca’s Epanova—a highly processed carboxylic acid form of EPA and DHA– failed to deliver the expected reduction in major cardiovascular events observed during 2019’s REDUCE-IT trial using the fish oil-based Vascepa EPA. The just-published multicenter STRENGTH trial  ( (STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia) randomized 13,078 high-risk patients […]

Providing Help at the Intersection of Pain Place & Depression Boulevard

By Russell Jaffe, MD

Depression, anxiety, and chronic pain frequently co-occur, though the connection between them is not always apparent at the outset. While most people experience physical pain at some point in their lives, in those with depression or anxiety, pain can become particularly intense and hard to treat. People suffering from depression, for example, tend to experience more severe […]

Bolstering Mucosal Barriers is Key to Boosting Immunity

By Mark Engelman, MD & Chad Larson, NMD, DC

The COVID-19 pandemic, along with the onset of flu season, have a lot of people thinking about their immune systems, and seeking ways to improve resilience to viruses and other types of infection. The best way to help patients strengthen their immunity is to work with them to optimize gut health and strengthen epithelial barriers. […]