Chronic Disease

Glycocalyx Restoration is Key for Lowering CVD Risk

By Erik Goldman

Repair of the endothelial glycocalyx is a vital element in the restoration of cardiovascular health, according to Mark Houston, MD, director of the Hypertension Institute at Saint Thomas West Hospital, Nashville. The endothelial glycocalyx (EGX) —literally “sugar coating” in Greek—is a very thin gel-like layer that lines the luminal surface of the blood vessels. It […]

Uric Acid is Detrimental to Gut Health

By Kristen Schepker

“People who suffer from chronic elevated uric acid tend to harbor unhealthy biomes,” says neurologist David Perlmutter, MD.

In his latest book, Drop Acid: The Surprising New Science of Uric Acid, Perlmutter presents several studies showing that adverse changes in the gut microbiome directly relate to our ability to metabolize and eliminate uric acid (UA).

The intricate interplay between hyperuricemia and the gut microbiome is still a relatively new field of research. But it has already led to some interesting discoveries.

Dropping (Uric) Acid with Dr. David Perlmutter

By Kristen Schepker

Conventional medical wisdom holds that uric acid is a harmless, inert form of metabolic waste, and most physicians were trained to see it as a “trivial, incidental byproduct of our normal biology.” But contemporary research reveals that this compound is “anything but meaningless or unworthy of our attention,” says neurologist David Perlmutter, MD. In his […]

Leveraging the Power of Probiotics To Treat Liver Disease

By Erik Goldman

Probiotics could be an important piece of the therapeutic puzzle for people with hepatic cirrhosis and other forms of progressive liver disease. Research from around the world is shedding light on the so-called “gut-liver axis” and the ways in which the gut microbiome affects liver function, both negatively and positively.  This work opens up promising […]

FODMAPS & IBS: Don’t Throw the Baby Out with the Bathwater

By Sally LaMont, ND. LAc

What do apples, onions, hummus, and ice cream have in common? They’re all rich in FODMAPs: a set of short-chain carbohydrates that can set off the symptoms of irritable bowel syndrome (IBS), such as bloating, gas, cramping, constipation and/or diarrhea. Short-term adherence to FODMAP-free diets can be very effective in reducing the symptom burden associated […]

Assessing Early Stage Cardiovascular Damage

By Charles K. Bens, PhD, Contributing Writer

A number of assessment tools can be used to determine if a patient is at risk of myocardial damage caused by cardiometabolic disease and/or COVID infection. Many of these tests also reflect the general dysfunction of cellular metabolism that underlies a host of chronic conditions. Vitamin D3 Level: There are so many good reasons to […]

Addressing the Repair Deficits That Underlie Chronic Pain

By Russell Jaffe, MD, Contributing Writer

Roughly one in five people suffers from chronic pain of some sort. It is one of the leading causes of disability, reduced productivity, and escalating medical care costs.  While pain is often multifactorial, there’s a lot we as clinicians can do to help our chronic pain patients once we understand the relationship between inflammation, repair […]

VITAL: Vitamin D, Omegas Reduce Autoimmune Disease Risk

By Erik Goldman

Data from the massive Vitamin D and Omega-3 Trial (VITAL) show clearly that daily supplementation with 2,000 IU of vitamin D can reduce the incidence of rheumatoid arthritis, polymyalgia rheumatica, and other autoimmune conditions. Omega-3 fatty acids, at a dose of 1,000 mg per day also mitigated risk, but to a lesser degree. “Vitamin D […]

Ten Nutraceuticals for Repairing Cardiovascular Damage

By Charles K. Bens, PhD, Contributing Writer

Emerging research is challenging the long-held belief that tissue damage following myocardial infarction is permanent and irreversible. For decades, the conventional medical view has been that damaged myocardium cannot regenerate, owing to the fact that heart cells are not as readily replaced as are other cells in the body. Several research teams around the world, […]

“Next-Generation” Microbes & Probiotics for Metabolic & Immune Health

By Erik Goldman

The gut microbiome exerts profound influence on immunological and metabolic health.   Recent research points to two “next generation” microbes– Akkermansia muciniphila and Faecalibacterium prausnitzii –as especially important metabolically and immunologically. In healthy people, these organisms are plentiful.  But they are found at much lower levels in people with obesity and other metabolic and inflammatory diseases. […]