Uric Acid is Detrimental to Gut Health

“People who suffer from chronic elevated uric acid tend to harbor unhealthy biomes,” says neurologist David Perlmutter, MD.

In his latest book, Drop Acid: The Surprising New Science of Uric Acid, Perlmutter presents several studies showing that adverse changes in the gut microbiome directly relate to our ability to metabolize and eliminate uric acid (UA).

The intricate interplay between hyperuricemia and the gut microbiome is still a relatively new field of research. But it has already led to some interesting discoveries.

FDA & AMA Team Up to “CMEar” Dietary Supplements

If you want to understand why so many Americans distrust the Food and Drug Administration and the medical mainstream, look no further than the FDA’s new online medical education program on dietary supplements. Produced in collaboration with the American Medical Association, this three-part continuing medical education (CME) course—and I use that term loosely—is part of […]

In Memoriam: Stephen Sinatra, MD

We at Holistic Primary Care are saddened to learn of the passing of Dr. Stephen Sinatra, on Father’s Day 2022, just four months shy of his 76th birthday. A trailblazer in the field of metabolic cardiology, Dr. Sinatra was an exemplary physician, healer, and teacher. Though trained in the conventional biomedical paradigm, he realized early […]

Dropping (Uric) Acid with Dr. David Perlmutter

Conventional medical wisdom holds that uric acid is a harmless, inert form of metabolic waste, and most physicians were trained to see it as a “trivial, incidental byproduct of our normal biology.” But contemporary research reveals that this compound is “anything but meaningless or unworthy of our attention,” says neurologist David Perlmutter, MD. In his […]

Food Triggers, Immune Dysregulation, and Autoimmunity

We hear a lot these days about the impact of diet for boosting immunity. While it is true that carrots, kale, or oranges are good sources of immunity-boosting phytochemicals, it is also true that foods—even ‘healthy’ foods– can also cause immune dysregulation or autoimmune disorders in some patients. Compounds—especially dietary proteins– within ordinary foods, are […]

A 5% Investment in Self-Care Gives Big Health Payoffs

Many people think “getting healthy” requires a total lifestyle overhaul, a major investment of time and money, and a lot of work.  Too often, those expectations solidify into an insurmountable obstacle, people feel intimidated, and consequently they never set out on the journey to better health. The truth is, devoting just 5% of the day […]

Microplastics & the Microbiome: A Complex Interaction

If you’ve seen the classic 1967 film, The Graduate, you’ll surely remember the infamous graduation party scene when family friend Mr. McGuire offers bewildered young Ben Braddock (Dustin Hoffman) a bit of advice: “I just want to say one word to you…..just one word,” says McGuire. “Are you listening? Plastics! There’s a great future in […]

Leveraging the Power of Probiotics To Treat Liver Disease

Probiotics could be an important piece of the therapeutic puzzle for people with hepatic cirrhosis and other forms of progressive liver disease. Research from around the world is shedding light on the so-called “gut-liver axis” and the ways in which the gut microbiome affects liver function, both negatively and positively.  This work opens up promising […]

FODMAPS & IBS: Don’t Throw the Baby Out with the Bathwater

What do apples, onions, hummus, and ice cream have in common? They’re all rich in FODMAPs: a set of short-chain carbohydrates that can set off the symptoms of irritable bowel syndrome (IBS), such as bloating, gas, cramping, constipation and/or diarrhea. Short-term adherence to FODMAP-free diets can be very effective in reducing the symptom burden associated […]

Non-Rx Female Hormone Support Made Simple

Bioidentical Hormone Replacement Therapy (BHRT) has improved the lives of millions of perimenopausal and menopausal women. But let’s face it: fulfilling BHRT prescriptions at compounding pharmacies is a hassle for patients and practitioners alike. It is also a lost revenue stream for practitioners. There has never been a comprehensive non-prescription hormone balancing system that delivers […]