Low Folate, MTHFR Polymorphisms Raise Risk of Congenital Heart Defects
Low folate status, combined with a cluster of certain folate-metabolizing genetic variants, is associated with increased risk of congenital heart disease (CHD). Mothers and children with certain polymorphisms within the MTHFR, MTR, and MTRR genes showed decreased folate and elevated homocysteine levels, both significant risk factors for CHD.