The Transformative Benefits of Nicotinamide Riboside and NAD+: Targeting a Root Cause of Aging

According to the World Health Organization (WHO), “At the biological level, aging results from the impact of the accumulation of a wide variety of molecular and cellular damage over time.”

Age-related functional decline occurs from exposure to physiological and metabolic stressors that cause subsequent epigenetic changes. Overall health depends, in large part, on cellular resilience to these stressors.

Research suggests that a critical coenzyme called nicotinamide adenine dinucleotide (NAD+) is an important factor in cellular resilience. NAD+ plays an essential role in maintaining healthy mitochondrial and cellular function. It activates DNA repair mechanisms, and helps cells resist the effects of metabolic stressors.

The different forms of vitamin B3 serve as NAD+ precursors. While the RDA for vitamin B3 (about 15mg/day) is sufficient to prevent pellagra, it may not be sufficient to support optimal mitochondrial health. Subclinical NAD+ deficiency is hypothesized to be a common factor of aging.

In this webinar, Andrew Shao, PhD, shares insight on why and how to boost NAD+ to support cellular energy and healthy aging. You’ll discover how achieve NAD+ repletion through supplementation with NAD+ precursors, and why Nicotinamide Riboside (NR) is the most efficient precursor for boosting NAD+

You’ll Learn:

  • How cells use NAD+ to support energy production and cellular metabolism
  • The factors that disrupt NAD+ homeostasis and deplete the NAD+ pool
  • The importance of NAD+ repletion and the use of NAD+ precursors
  • The properties and functions of Nicotinamide Riboside, a unique form of vitamin B3, and an NAD+ precursor.


Andrew Shao, PhD, has spent over two decades in the global nutrition industry, serving in leadership roles on nutritional, scientific, regulatory and government affairs issues. He currently serves as Senior VP of Global Scientific & Regulatory Affairs for ChromaDex, Inc. where he oversees scientific, regulatory, R&D, and quality assurance efforts.  Prior to joining ChromaDex Dr. Shao held leadership positions at Herbalife Nutrition, and served as Senior VP of Scientific & Regulatory Affairs for the Council for Responsible Nutrition (CRN). Before joining CRN, he was a senior scientist at General Nutrition Corporation (GNC), and previously, in research and development at Kemin

Dr. Shao holds a doctorate in nutritional biochemistry and master’s in human nutrition science, both from Tufts University. He is an author on over 60 peer-reviewed articles, abstracts, trade articles, and book chapters. He is Chairman of the Sustaining Partners Roundtable of the American Society for Nutrition, and member of the Tufts Nutrition Council.

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