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Required Reading on GLPs: Ashley Koff’s “Your Best Shot”

By Robert Bonakdar, MD, Contributing Writer

GLP-1–based therapies, including glucagon-like peptide-1 receptor agonists (e.g., semaglutide), dual incretin agonists (e.g. tirzepatide), and forthcoming GLP-1–modulating drugs like retatrutide, have rapidly reshaped the clinical management of obesity, type 2 diabetes, and cardiometabolic disease. In less than a decade, these drugs have moved from the weight management and endocrinology niches to much wider use in […]

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Is Male Infertility Contributing to Falling Birth Rates?

By Joshua Cohen

(This article was originally published on Dec. 3, 2025 on Undark.) For decades, U.S. marriage rates have been on the decline while the average age at which Americans have children has risen. Alongside this, birth rates have dropped — a phenomenon the Health and Human Services Secretary Robert F. Kennedy, Jr. has called a “national […]

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For Depression, Transcranial Magnetic Stimulation Shouldn’t Just Be a Last Resort

By ichael C. Marone

(This article was originally pubished on Dec. 11, 2025, on Undark) For decades, the treatment of clinical depression has followed the same outdated flow chart: Try one antidepressant, then another, then a combination, then maybe just one more. Finally, when all pharmaceutical attempts fail, consider other approaches. This protocol, called step therapy, has come under […]

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What Anti-Vaccine Policies Could Mean for Autoimmune Diseases

By Giamila Fantuzzi, PhD

(This article originally appeared on Dec. 17, 2025 on www.Undark.org) Autoimmune diseases disproportionately affect women. This is especially true for lupus (formally known as systemic lupus erythematosus), as about nine in 10 people with the condition are female. Lupus can cause inflammation and pain and commonly affects the skin, joints, and organs including the heart […]

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Will San Francisco Out-MAHA the Fed on Processed Foods?

By Janet Gulland, Contributing Writer

In a move that could out-MAHA MAHA, the City of San Francisco is suing Kraft Heinz, Coca Cola, Nestle, Kellogg, and six other producers of ultra-processed junk foods, claiming the companies have knowingly “engineered a public health crisis” by marketing highly addictive, nutrient-poor, sugar- and salt-laden foods linked to higher incidence of diabetes, fatty liver, […]

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Exploring the Gut-Bone Connection

By John Neustadt, ND, Contributing Writer

Extensive research over the past several decades has revealed a dynamic connection between the gut and the bones. It turns out that bone health and strength is closely tied to the health of the digestive system. Gastrointestinal disorders contribute to the development of osteoporosis and, by extension, risk of fractures. This line of research suggests […]

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Krill Oil Protects Muscle During Intensive Weight Loss

By Erik Goldman, Editor

For overweight people, diet-based weight loss interventions are a critical factor in restoring health. But dieting alone without concurrent exercise—which is the reality for many—results in loss of skeletal muscle along with the fat. And that can be very problematic. Some studies indicate that loss of fat-free mass (aka muscle) accounts for between 25%–30% of […]

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Beacons Through the (Brain) Fog: Corey Schuler on Holistic Approaches to Cognitive Dysfunction

By Erik Goldman, Editor in Chief

Assessing and treating cognitive dysfunction is a challenge. The problems can show up in myriad ways, with multiple potential causes. Cognitive impairment is often connected with, and reflective of, disease and dysfunction in other organ systems. Though surveys consistently show that many people worry about developing dementia, individual patients may not always be forthright about […]

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Helpful Herbs & Nutrients for Brain Health

By August West, Contributing Writer

“Brain Health” is one of the largest and fastest growing segments of the natural healthcare industry.  Americans will spend close to $1.5 billion on cognition-related products by the end of this year, according to Nutrition Business Journal (NBJ). Globally, the market for brain health products is projected to grow from its current $8.2 billion, to […]

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