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Massive New Study Ties Long-Term Statin Use To Sarcopenia, Loss of Strength

By Erik Goldman

Data from nearly 300,000 UK citizens tracked over an average of 10 years show that constant statin use results in a progressive loss of grip strength and lean muscle mass, independent of demographic, genetic, and lifestyle variables. (Image: ArtemisDiana/Shutterstock)

Analysis of data from nearly 300,000 UK citizens tracked over a 20-year period shows a decline of up to 25% in grip strength, and a 73% drop in appendicular lean mass (ALM), among continuous statin users compared with people who’d never taken statins.

Grip strength diminished by a mean of 0.315 kg per year from baseline among the statin users, and ALM showed a parallel reduction of 0.057 kg per year. Notably, these changes were independent of genetic predisposition to statin responsiveness, as well as demographic variables including age, gender, BMI, and co-morbidities.

“Continuous statin use is associated with a decline in muscle function and mass over time, irrespective of genetic susceptibility to statin response,” writes lead investigator Mélissa Gentreau, PhD, a Functional Pharmacologist at the Department of Surgical Sciences, Uppsala University, Sweden.

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Featured Articles

Are Power Grids & Mobile Phones Raising Diabetes Risk?

Written by Magda Havas, BSc, PhD, Contributing Writer

The enormous networks of electricity and wireless radiation surrounding our modern lives may be quietly rewiring the way our cells make energy. In doing so, they could be contributing to the surging incidence of type 2 diabetes. That’s the main conclusion of a new scientific analysis by McGill University biophysicist, Paul Héroux, PhD.  Published as […]

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New Lyme Diagnostics on Near Horizon

Written by Erik Goldman

Diagnostic tests for Lyme disease may soon get a major upgrade, as seven innovative research and development teams ready their novel methods for review by the Food & Drug Administration. If the FDA deems them market-ready, these new tests could dramatically improve physicians’ abilities to detect early-stage, as well as latent and chronic Borrelia burgdorferi […]

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HPC Video

Redox, Repair, and Resilience: Breaking the Sympathetic Spiral of Doom with Methylene Blue and GABA Modulation

Written by Erik Goldman

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Modern life keeps our foot glued to the sympathetic gas pedal—creating a spiral of stress, inflammation, and mitochondrial breakdown. In this free webinar, Dr. Scott Sherr explores how clinicians can break that “Sympathetic Spiral of Doom” by restoring mitochondrial redox balance with methylene blue and rebalancing the nervous system through targeted GABAergic modulation. 

We’ll examine methylene blue as both a redox cycler and mitochondrial rescue agent, reviewing evidence from models of ischemia, infection, and neuroinflammation. You’ll learn clinical indications and practical dosing strategies, as well as the safety considerations that separate high-quality pharma-grade methylene blue from contaminated or subtherapeutic versions commonly found online.

We’ll also connect the dots between mitochondrial dysfunction and GABA deficiency, and show how combining methylene blue with GABA orthosteric and allosteric ligands creates a synergistic, precisely dosed combination that rapidly restores balance between sympathetic overdrive and parasympathetic repair.

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