Transmission electron micrograph of capillary, with four erythrocytes. The outer surface of the endothelial cells is coated by an electron-opaque glycocalyx (purple). Glycocalyx damage is the earliest step in the progression to atherosclerosis. (Image: OMIKRON/Science Photo Library)
Repair
of the endothelial glycocalyx is a vital element in the restoration of
cardiovascular health, according to Mark Houston, MD, director of the
Hypertension Institute at Saint Thomas West Hospital, Nashville.
The endothelial glycocalyx (EGX) —literally “sugar coating” in
Greek—is a very thin gel-like layer that lines the luminal surface of the blood
vessels. It is a carbohydrate-rich mesh of membrane-bound and soluble
glycoproteins, proteoglycans, and glycosaminoglycans, which create a
non-adherent shield.
Damage to this sensitive, bioactive layer is one of the earliest
steps in the pathogenesis of cardiovascular disease, Dr. Houston said at the
2022 Integrative Healthcare Symposium.
Daily supplementation with a fixed dose combination of nicotinamide riboside, L-carnitine, L-serine, and N-acetyl cysteine significantly reduced liver fat, quelled oxidative stress, and improved liver enzyme profiles in a cohort of 31 patients with non-alcoholic fatty liver disease (NAFLD). Defined as hepatic fat accumulation of 5% or more, unrelated to alcohol consumption or other liver […]
Mast cell activation syndrome—a multi-system disorder characterized by aberrant activity of these key immune cells—is widely prevalent, and on the rise as the world becomes more toxic, infectious, and stressful, says Tania Tyles Dempsey, MD, a clinician who specializes in this common but mis-diagnosed problem. The syndrome differs from mastocytosis or mast cell cancers in […]
Metabolic
disorders, especially overweight and obesity, diabetes, and dyslipidemia are
some of the most common illnesses all over the world, carrying a high burden of
cardiovascular morbidity and mortality.
In this free webinar, renowned integrative physician Fred Pescatore, MD, will share the science on a soy-derived fibrinolytic enzyme called Bacillopeptidase F, which is shown to improve circulation and normalize biomarkers associated with metabolic disorders.
These
biomarkers include: Hemoglobin A1c, fibrinogen, hS-CRP, total Cholesterol,
HDL-cholesterol, LDL- cholesterol, triglycerides and more.
Isolated from natto, a traditional Japanese
fermented soy food, Bacillopeptidase F Proprietary Blend (BFFB) is a
fibrinolytic protease which can reduce plasminogen activator inhibitor (PAI-1).
When elevated, PAI-1 can impede normal blood circulation.
BFPB, available
as a dietary supplement called Plasmanex1® from Daiwa
Health Development,
maintains
healthy circulation by keeping plasmin and thrombin in balance. It improves circulation, but does not thin the
blood or interfere with blood-thinning medications.
Readily available cardiometabolic biomarkers for
assess and follow-up of varied patient groups
The uses of BFPB in the clinical setting to
optimize patient care
The potential impact of this unique soy-derived
compound in clinical care
Fred Pescatore, MD, MPH, is a Manhattan-based conventionally trained
internist who specializes in nutritional medicine. He is a globally renowned
health, nutrition, and weight loss expert, as well as the author of 9 books
including the New York Times bestsellers, The Hamptons Diet, and The A-List Diet. He is the former president of the International and American
Association of Clinical Nutritionists.
Following a residency at New York Medical
College, Dr. Pescatore’s extraordinary journey in complementary
medicine began in the early 1990s with Dr. Robert Atkins at the Atkins Center
for Complementary Medicine. He then opened his globally recognized medical
center, Medicine 369, in New York City. His rapid expanding practice is
credited as one of the most effective and successful integrative medical centers
in the world, helping tens of thousands of people over in his thirty years of
clinical experience. Dr. Pescatore has studied in America, Southeast Asia,
India, Japan, Africa, and Europe, and is sought after as one of the frontline
educators and visionaries improving health care and human life.
