Estrogen metabolism is a forking path, creating two kinds of metabolites: the 16-hydroxyestrogens, which are highly inflammatory and promote cell growth and division; and the 2-hydroxyestrogens, which are anti-inflammatory and inhibit cell division. Over production of the 16-hydroxyestrogens is associated with increased risk of cancer and inflammatory diseases. Di-indolyl methane, a compound found naturally in broccoli and other cruciferous vegetables helps shift the balance in a healthier direction.