Vitamins & Supplements

Regulatory Confusion Reigns As FDA Grapples With CBD

By Erik Goldman, Editor in Chief

On July 30, former FDA Commissioner, Scott Gottlieb, published an op/ed in the Washington Post saying that the agency needs to get a grip on the "out of hand" CBD craze. But it's a tall order. In many ways, CBD epitomizes all the conflicting motives and scientific ambiguities with which the FDA must constantly contend.

Envisioning the Future of Dietary Supplement Regulation

By Erik Goldman, Editor in Chief

In the 25 years since Congress passed the Dietary Supplement Health and Education Act (DSHEA), the supplement industry has grown from cottage industry to multi-billion dollar global business. Rapid growth, the introduction of new ingredients, the globalization of the raw materials supply chain, the widespread use of genetically-modified ingredients, and the growing threat of economically-motivated product adulteration are  challenging DSHEA in ways its original framers could not have envisioned.

Delta-Tocotrienol Reverses Metabolic Syndrome, Fatty Liver

By Janet Gulland, Contributing Writer

Twice daily supplementation with δ-tocotrienol, one of the eight isoforms of vitamin E, produced marked reductions of body mass index, triglyceride levels, markers of inflammation, and liver enzymes in a cohort of overweight patients with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).

Zinc Carnosine Prevents Oral Mucositis

By Janet Gulland

Oral administration of polaprezinc (zinc L-carnosine) can prevent oral mucositis in cancer patients undergoing radiation or high-dose chemotherapy, according to a series of studies from researchers in Japan. The compound may also be useful in preventing or minimizing more common oral lesions like canker sores.

Webinar: The Broken Promise of Vitamin E--Why Annatto-Sourced Tocotrienols Are the "21st Century E"

By Erik Goldman

Barrie Tan Webinar Pic

VIEW WEBINAR

Over the years, vitamin E supplementation has been promoted for prevention or mitigation of everything from cardiovascular disease to Parkinson’s. In clinical trials, however, vitamin E has rarely lived up to its potential.

That’s because most studies only use alpha-tocopherol---just one of the eight tocopherols and tocotrienols that comprise vitamin E. Recent research suggests that alpha-tocopherol may not be the most powerful of the eight. Taken alone, it may actually be detrimental.  

Annatto (Bixa Orellana), an Amazonian tree that produces bright red seeds, has been used as a source of food and oil since 3,600 BCE. Modern research shows that annatto contains tocotrienol, a phytonutrient with extraordinary antioxidant properties. Annatto is the only plant source to provide exclusively the delta- and gamma-tocotrienols-- the most potent forms of vitamin E. Annatto is also free of tocopherols, an important feature since alpha-tocopherol interferes with tocotrienol biochemistry.

This webinar will cover milestones in vitamin E research, with special emphasis on distinguishing between tocopherols and tocotrienols, and the ways in which the widely used alpha-tocopherol interferes with tocotrienol function.

VIEW WEBINAR

Dr. Barrie Tan, one of the world’s experts on vitamin E, will share clinically relevant data on tocotrienol’s anti-oxidant and anti-inflammatory properties in the context of cardiometabolic disease, non-alcoholic fatty liver disease, cancer, bone health, and overall cellular health. An overview of the latest randomized trials will highlight annatto tocotrienol’s role as the “21st century vitamin E.”

LEARNING OBJECTIVES:

  • The origins of vitamin E, it’s 8 isomers, and the diverse sources from which they’re derived.
  • How the widely use alpha-tocopherol interferes with tocotrienol functions
  • The impact of annatto tocotrienol on cardiometabolic and cellular health
  • The benefits of annatto-derived tocotrienol with regard to healthy aging, and cardiometabolic, liver, bone, and cellular health.
  • Guidelines for appropriate tocotrienol dosing for practitioners and consumers

Dr. Barrie Tan is a trailblazer and the world’s foremost expert on vitamin E. A scientist first and foremost, he earned his PhD in Chemistry/Biochemistry from the University of Otago, New Zealand and spent several years as a professor at UMass. Credited with discovering a form of vitamin E called tocotrienol in three major sources – Palm, Rice, and Annatto, Dr. Tan was dubbed the “Tocotrienol King” by Dr. Stephen Sinatra, a highly respected integrative cardiologist. Dr. Tan is the President of American River Nutrition, a natural health R&D company he started with his wife, Elizabeth, in 1998. Today, his research focuses on lipid-soluble nutrients that reduce and slow chronic conditions.

VIEW WEBINAR

Can Probiotics Regulate Lipid Metabolism?

By Carrie Decker, ND, Contributing Writer

There’s ample data to show that gut bacteria affect mood, immune system health, sleep cycles, and response to stress. It turns out that the gut microbiome—at least certain microbial species within it—also play a role in lipid metabolism, suggesting that some types of probiotics may have heart health benefits.

Low Folate, MTHFR Polymorphisms Raise Risk of Congenital Heart Defects

By Kristen Schepker, Assistant Editor

Low folate status, combined with a cluster of certain folate-metabolizing genetic variants, is associated with increased risk of congenital heart disease (CHD). Mothers and children with certain polymorphisms within the MTHFR, MTR, and MTRR genes showed decreased folate and elevated homocysteine levels, both significant risk factors for CHD.