Glycocalyx Restoration is Key for Lowering CVD Risk

By Erik Goldman

Transmission electron micrograph of capillary, with four erythrocytes. The outer surface of the endothelial cells is coated by an electron-opaque glycocalyx (purple). Glycocalyx damage is the earliest step in the progression to atherosclerosis.
(Image: OMIKRON/Science Photo Library)

Repair of the endothelial glycocalyx is a vital element in the restoration of cardiovascular health, according to Mark Houston, MD, director of the Hypertension Institute at Saint Thomas West Hospital, Nashville.

The endothelial glycocalyx (EGX) —literally “sugar coating” in Greek—is a very thin gel-like layer that lines the luminal surface of the blood vessels. It is a carbohydrate-rich mesh of membrane-bound and soluble glycoproteins, proteoglycans, and glycosaminoglycans, which create a non-adherent shield.

Damage to this sensitive, bioactive layer is one of the earliest steps in the pathogenesis of cardiovascular disease, Dr. Houston said at the 2022 Integrative Healthcare Symposium.

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Clearing the Fog Around Mast Cell Activation Syndrome

Written by Erik Goldman

Mast cell activation syndrome—a multi-system disorder characterized by aberrant activity of these key immune cells—is widely prevalent, and on the rise as the world becomes more toxic, infectious, and stressful, says Tania Tyles Dempsey, MD, a clinician who specializes in this common but mis-diagnosed problem. The syndrome differs from mastocytosis or mast cell cancers in […]

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Nicotinamide Riboside Combo Formula Improves Hepatic Profiles in NAFLD

Written by August West, Contributing Writer

Daily supplementation with a fixed dose combination of nicotinamide riboside, L-carnitine, L-serine, and N-acetyl cysteine significantly reduced liver fat, quelled oxidative stress, and improved liver enzyme profiles in a cohort of 31 patients with non-alcoholic fatty liver disease (NAFLD). Defined as hepatic fat accumulation of 5% or more, unrelated to alcohol consumption or other liver […]

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HPC Video

Bacillopeptidase F: Its Impact on Metabolic Syndrome Disorder

Written by Erik Goldman

Metabolic disorders, especially overweight and obesity, diabetes, and dyslipidemia are some of the most common illnesses all over the world, carrying a high burden of cardiovascular morbidity and mortality.

In this free webinar, renowned integrative physician Fred Pescatore, MD, will share the science on a soy-derived fibrinolytic enzyme called Bacillopeptidase F, which is shown to improve circulation and normalize biomarkers associated with metabolic disorders. 

These biomarkers include: Hemoglobin A1c, fibrinogen, hS-CRP, total Cholesterol, HDL-cholesterol, LDL- cholesterol, triglycerides and more.

Isolated from natto, a traditional Japanese fermented soy food, Bacillopeptidase F Proprietary Blend (BFFB) is a fibrinolytic protease which can reduce plasminogen activator inhibitor (PAI-1). When elevated, PAI-1 can impede normal blood circulation.

BFPB, available as a dietary supplement called Plasmanex1® from Daiwa Health Development, maintains healthy circulation by keeping plasmin and thrombin in balance. It improves circulation, but does not thin the blood or interfere with blood-thinning medications.

In this program, you will learn about:

  • Readily available cardiometabolic biomarkers for assess and follow-up of varied patient groups
  • The uses of BFPB in the clinical setting to optimize patient care
  • The potential impact of this unique soy-derived compound in clinical care

Fred Pescatore, MD, MPH, is a Manhattan-based conventionally trained internist who specializes in nutritional medicine. He is a globally renowned health, nutrition, and weight loss expert, as well as the author of 9 books including the New York Times bestsellers, The Hamptons Diet, and The A-List Diet. He is the former president of the International and American Association of Clinical Nutritionists.

Following a residency at New York Medical College, Dr. Pescatores extraordinary journey in complementary medicine began in the early 1990s with Dr. Robert Atkins at the Atkins Center for Complementary Medicine. He then opened his globally recognized medical center, Medicine 369, in New York City. His rapid expanding practice is credited as one of the most effective and successful integrative medical centers in the world, helping tens of thousands of people over in his thirty years of clinical experience. Dr. Pescatore has studied in America, Southeast Asia, India, Japan, Africa, and Europe, and is sought after as one of the frontline educators and visionaries improving health care and human life.

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