Women & Autoimmune Disease: An “Xist”ential Question

By Janet Gulland, Contributing Writer

Stanford researchers have found evidence that an RNA sequence called “Xist,” which is only produced by biologically female (XX) mammals, is an important factor in the etiology of many autoimmune diseases (Image: Sergii Laramenko/Shutterstock)

The statistics have been clear and consistent for decades: autoimmune conditions are at least three times more common among women than men. Some studies suggest it’s more like a factor of four. For specific diseases like Lupus, the disparity is 9-fold. For Sjogren’s syndrome, it’s 19 to 1.

This appears to be an objective biological phenomenon. It’s not a reflection of gender-based differences in seeking medical care, or of misdiagnosis—though there’s plenty of that. Neither is it strictly hormone-related.

Hormonal factors do play some role in autoimmune disorders. But the hormonal differences between biologically female and male individuals in no way fully account for the marked disparity of autoimmune diseases.

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Featured Articles

Microplastics: A New Cardiovascular Risk Factor

Written by Erik Goldman

The presence of micro- or nano-plastic particles in carotid atheromas significantly raises the risk of myocardial infarction, stroke, or death from any cause within 3 years. That’s the blunt conclusion of a new multi-center study headed by researchers at the Department of Advanced Medical & Surgical Science, University of Campania, Naples, and involving more than […]

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Eczema: A Holistic Approach

Written by Janet Gulland, Contributing Writer

Eczema is seldom life-threatening, but it can have profoundly detrimental impact on the people it affects. Clinicians who can bring a holistic, root-cause approach to this common condition can make a big difference in the lives of their patients. “Roughly 20 million Americans have eczema. It’s a huge population. Patients are desperate for help, and […]

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HPC Video

Three Ways Supplement Companies Deceive You---And Your Patients

Written by Administrator

There are significant gaps in the regulation of the supplement industry, resulting in a situation where some companies are producing excellent, safe, and effective products with exacting quality standards, while others are not. 

In this free webinar, we’ll go over how you as a clinician, and your patients, can tell the difference.

Specifically, we will look at how some companies use fillers and flow agents to make the contents of their capsules look more substantial than they really are.  We will reveal specific instances where companies mislabel their supplement facts, and others where brands provide serving sizes are not biologically relevant. Lastly, we’ll look at one popular curcumin product that may actually be harmful.

Our presenters, Martin Katz, MD, and John Gildea, PhD, will cover:

  • How to determine how much filler is in a supplement capsule—and why that matters
  • Common supplement industry mislabeling tricks
  • Popular supplement ingredients that are typically not bioavailable enough to have clinically relevant impact on human physiology

SPONSORED BY Mara Labs

John Gildea, PhD, is a Johns Hopkins-trained pathologist and researcher, who has authored 60 scientific publications from over 20 NIH-funded studies. He is an expert in cell culture and exosomes, and directed all the science behind the gut supplement, RESTORE. Dr. Gildea was instrumental in the initial stabilization of the sulforaphane in BrocElite®.

Martin Katz, MD, is double board certified in Sports and Family Medicine. He is committed to a preventative medicine paradigm, educating his patients regarding the benefits of intentional nutrition, exercise, sleep, the microbiome, and connectivity. Dr. Katz earned his MD degree from the Medical University of South Carolina, and practices in Charlottesville, VA.

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