Fish Beats Wolf: Omega-3s Reduce Fatigue in Lupus Patients

A daily dose of omega-3 fatty acids can improve quality of life and reduce fatigue in patients with systemic lupus erythematosus (SLE), according to a study Fish oil sourcesby researchers at the University of Texas-Southwestern Medical Center, Dallas. 

The symptoms and severity of lupus can differ broadly from individual to individual. Fatigue, chronic pain and depression are among its most common features, with fatigue affecting more than 80% of all lupus patients.

Previous research indicates that people with lupus have low levels of serum omega-3s, which are known to promote healthy brain function and mood regulation (Wu, T. et al. PLoS ONE. 2012; 7(6): e37210, Kidd, P. Alt Med Rev. 2007; 12(3): 207-227). Numerous clinical trials have explored  fish oil supplementation as a possible treatment for lupus in general, though results vary widely.

Researchers have observed positive effects of omega-3s on depressive symptoms and overall quality of life in lupus patients (Grosso, G. et al. PLoS One. 2014; 9(5): e96905). But despite the high prevalence of fatigue associated with lupus, the impacts of omega-3s on this aspect of the disease have never been the focus of a clinical trial. . 

In addition to the existing research on omega-3s and depression, there are also data from a metabolomics study showing reduced markers of energy generation and amplified markers of oxidative stress and inflammation - indicators that correlate with fatigue - in SLE patients (Wu, T. et al. PLoS ONE. 2012; 7(6): e37210). These alterations, “may manifest physically and mentally as ill-defined symptoms of fatigue, generalized pain, and depressed mood.”

The new study brings a “novel assessment of fish oil’s effect on quality of life, fatigue, and a large panel of soluble mediators” to the existing body of lupus research.

Cristina Arriens and colleagues of the Division of Rheumatic Diseases, at the University of Texas looked specifically at lupus-related fatigue in a cohort of 50 patients with SLE treated at outpatient rheumatology and nephrology clinics affiliated with the UT center in Dallas.  The patients were between the ages of 18-64 years; 32 of the original 50 completed the full 6-month trial.

Key exclusion criteria included allergy to fish or fish oil; current use of fish oil or use within two months; warfarin or heparin use; and pregnancy. Participants continued receiving standard medical care throughout the trial from their primary physicians, who were blinded to the patients’ treatment groups (Arriens, C. et al. Nutr J. 2015; 14(82)).

During the study, patients took either a daily fish oil supplement (Metagenics) comprised of six capsules/day equaling 2.25g EPA and 2.25g DHA, or a visually identical olive oil placebo (six capsules/day, purified [refined, not extra-virgin] olive oil). The participants were allowed to divide their daily intake into one or two doses per day as desired.

More Fish, Less Fatigue

At baseline and again after six months, the investigators assessed the patients' overall health as well as the burden of lupus-related symptoms using the RAND Short Form-36 (RAND SF-36), Fatigue Severity Scale (FSS), SLE Disease Activity Index (SLEDAI), and Physician Global Assessment (PGA). They also collected serum for soluble mediator analysis.

At the end of the six month trial, they found that subjects in the fish oil group showed a trend in improvement on the Energy/fatigue subscale of the Rand SF-36 (median 10.00 [IQR - 1.25 – 21.25]) as compared to the placebo group (−2.50 [−6.25 – 11.25], p = 0.092).Lupus FishOil Data 1

Similarly, the fish oil group also did better on the SF-36 Emotional well-being subscale (16.00 [−1.00 – 33.00] vs. (4.00 [−5.00 – 14.00], p = 0.070). Higher scores in these two areas are “indicative of better quality of life or fatigue,” the researchers note.

While Fatigue Severity Scale scores remained similar between both groups (fish oil −0.056 [−1.500 – 0.500] vs. placebo 0.222 [−0.556–0.667], p = 0.350), the fish oil patients showed greater improvements in global disease activity, as measured by the Physician Global Assessment (−0.550 [−1.275– - 0.100] vs. (0.50 [−0.200–0.350]), p = 0.015).

Objective biochemical measures also indicated a change for the better in the fish oil group. The authors noted improvements in a number of biomarkers of inflammation. The Erythrocyte Sedimentation Rate (ESR), “an accepted measure of systemic inflammation,” reduced significantly in the fish oil group as compared to the placebo group (−5.0 [−39.0– -2.5] vs. 4.5 [0.0–19.0], p = 0.008).

“Among the cytokines/chemokines/growth factors studied, we observed an increase in the level of IL-13,” a T-cell secreted anti-inflammatoryLupus FishOil Data2 cytokine, in patients who took the fish oil supplement (−3.89 [−17.37–38.55] vs. placebo −16.86 [−46.25–2.31], p = 0.033). Dr. Arriens and colleagues also saw a drop in IL-12, a pro-inflammatory cytokine that is elevated in SLE patients (fish oil −16.13 [−78.50–26.37] vs. placebo 8.54 [−14.16–113.35], p = 0.058).

Though the study was limited in size, the authors conclude that many “positive indications...for quality of life, fatigue, disease activity, and inflammation biomarkers” in the test group align with previous studies pointing to fish oil’s numerous potential benefits in SLE treatment.

Fish oil supplements are widely available, relatively inexpensive, and generally safe: it makes good clinical sense to consider them as an adjunct modality in the care of people with SLE and possibly other forms of lupus.