Glycation--a process by which sugars bind to proteins forming inflammatory compounds--is at the center of the chronic disease storm. Clinicians need to understand as much as possible about this process and the interventions that can be used to attenuate it.
Twenty years ago, Dr. Stephen Sinatra was like most American cardiologists: firmly convinced that elevated cholesterol was the key driver of heart disease, and that thanks to statin drugs, he and his colleagues would soon be cutting the nation’s number one killer down to size.
Despite our nation’s best effort to treat all forms of cardiovascular disease aggressively, we seem to be losing the struggle.
The Daniel Plan, a holistic health initiative co-developed by a mega-church pastor and some of the pioneers in functional medicine is proving highly effective in motivating people to make meaningful and lasting lifestyle changes.
There are strong correlations between celiac disease and other causes of intestinal permeability and common disorders of the bones and joints. Autoimmune reactions, facilitated by increased intestinal permeability, is sometimes an underlying cause of arthritis and osteoporosis.
Drug therapies to reduce cardiovascular risk and prevent the onset of diabetes may be effective in the short term, but as people age, the efficacy of drugs like statins and metformin tends to diminish, while the risk of adverse effects increases. The benefit of nutritional and lifestyle interventions, on the other hand, remains robust even as people enter their final decades.
A new and interesting angle on the vitamin D story is emerging from research on weight gain in older women. The vitamin, it seems, is an important metabolic signal that indirectly regulates the propensity to store fat.